概述

  • 产品名称Anti-TDP1抗体
    参阅全部 TDP1 一抗
  • 描述
    兔多克隆抗体to TDP1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region between residues 1 and 50 of human TDP1 (NP_001008744.1)

  • 阳性对照
    • Human Anaplastic Thyroid Carcinoma, Breast Carcinoma, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Prostate Carcinoma and Stomach Adenocarcinoma tissues.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab84747 was affinity purified using an epitope specific to TDP1 immobilized on solid support.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
    • 组织特异性Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus.
    • 疾病相关Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy
    • 序列相似性Belongs to the tyrosyl-DNA phosphodiesterase family.
    • 翻译后修饰Phosphorylated on serine and/or threonine residues, but not on tyrosine residues.
    • 细胞定位Nucleus. Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AI838772 antibody
      • AW493413 antibody
      • FLJ11090 antibody
      • MGC104252 antibody
      • MGC112732 antibody
      • RP24-311F12.2 antibody
      • SCAN1 antibody
      • TDP1 antibody
      • TYDP antibody
      • TYDP1_HUMAN antibody
      • Tyr-DNA phosphodiesterase 1 antibody
      • Tyrosyl-DNA phosphodiesterase 1 antibody
      see all

    Anti-TDP1 antibody 图像

    • ab84747 at 1/250 dilution staining TDP1 in human ovarian tumor by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
    • ab84747 at 1/250 dilution staining TDP1 in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    Anti-TDP1 antibody (ab84747)参考文献

    ab84747 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"