生物素Anti-TCR gamma + TCR delta抗体[UC7-13D5] (ab25209)
Key features and details
- Biotin Armenian hamster monoclonal [UC7-13D5] to TCR gamma + TCR delta
- Suitable for: IHC-Fr, IP, Flow Cyt, Functional Studies
- Reacts with: Mouse
- Conjugation: Biotin
- Isotype: IgG
Related conjugates and formulations
概述
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产品名称
生物素Anti-TCR gamma + TCR delta抗体[UC7-13D5]
参阅全部 TCR gamma + TCR delta 一抗 -
描述
生物素亚美尼亚仓鼠单克隆抗体[UC7-13D5] to TCR gamma + TCR delta -
宿主
Armenian hamster -
偶联物
Biotin -
特异性
ab25209 is specific for the gamma-delta heterodimer and plate-bound ab25209 activates gamma-delta TCR bearing cells. This antibody does not react with alpha-beta TCR-expressing T cells. -
经测试应用
适用于: IHC-Fr, IP, Flow Cyt, Functional Studiesmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to TCR gamma + TCR delta. Mouse T cell clone G8
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark. -
存储溶液
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Affinity purified -
克隆
单克隆 -
克隆编号
UC7-13D5 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab25209于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-Fr |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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Flow Cyt |
Use at an assay dependent concentration.
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Functional Studies |
Use at an assay dependent concentration.
In vitro activation of gamma-delta TCR-bearing cells and depletion of gamma-delta TCR-expressing cells. |
说明 |
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IHC-Fr
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. |
Functional Studies
Use at an assay dependent concentration. In vitro activation of gamma-delta TCR-bearing cells and depletion of gamma-delta TCR-expressing cells. |
靶标
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相关性
T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one a and one b chain or one d and one g chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. The g/d TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most g/d T cells are CD4-/CD8-, some are CD8+. T cells expressing the g/d TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. -
细胞定位
Type I membrane protein -
别名
- CD_antigen=CD3d antibody
- CD3D antibody
- CD3G antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab25209 被引用在 1 文献中.
- Dent AL et al. Self-reactive gamma delta T cells are eliminated in the thymus. Nature 343:714-9 (1990). PubMed: 1968227