Anti-TCR gamma + TCR delta抗体[UC7-13D5] (ab25252)

概述

  • 产品名称Anti-TCR gamma + TCR delta抗体[UC7-13D5]
    参阅全部 TCR gamma + TCR delta 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[UC7-13D5] to TCR gamma + TCR delta
  • 特异性This antibody does not react with alpha-beta TCR expressing cells.
  • 经测试应用适用于: Flow Cyt, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    The details of the immunogen for this antibody are not available.

  • 常规说明


    This antibody has been shown to be useful in studies of in vitro activation of gamma-delta TCR bearing cells and in vitro depletion of gamma-delta TCR expressing cells.

性能

应用

Our Abpromise guarantee covers the use of ab25252 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 3µg for 106 cells. ab18479-Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.

靶标

  • 相关性T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one a and one b chain or one d and one g chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. The g/d TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most g/d T cells are CD4-/CD8-, some are CD8+. T cells expressing the g/d TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease.
  • 细胞定位Type I membrane protein
  • 数据库链接
  • 别名
    • CD_antigen=CD3d antibody
    • CD3D antibody
    • CD3G antibody
    • T cell antigen receptor delta polypeptide antibody
    • T cell antigen receptor gamma polypeptide antibody
    • T cell rearranging gene gamma antibody
    • T cell receptor delta antibody
    • T cell receptor delta locus antibody
    • T cell receptor gamma antibody
    • T cell receptor gamma chain C region PT gamma 1/2 antibody
    • T cell receptor gamma cluster antibody
    • T cell receptor gamma locus antibody
    • T cell receptor T3 delta chain antibody
    • T cell receptor, delta (V,D,J,C) antibody
    • T cell receptors antibody
    • T cell surface glycoprotein CD3 delta chain antibody
    • T-cell receptor T3 gamma chain antibody
    • T-cell surface glycoprotein CD3 gamma chain antibody
    • T3D antibody
    • T3G antibody
    • TCRD antibody
    • TCRDV1 antibody
    • TCRG antibody
    • TRD antibody
    • TRD locus antibody
    • TRD@ antibody
    • TRG antibody
    • TRG locus antibody
    • TRGC2 antibody
    see all

Anti-TCR gamma + TCR delta antibody [UC7-13D5] (ab25252)参考文献

ab25252 has not yet been referenced specifically in any publications.

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We do not perform epitope mapping in-house, however the below reference article states that this clone recognizes all murine TCR gamma and deltaheterodimers.

Bluestone, J.A., et al. 1991. Immunol. Rev. 1...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"