Anti-TCR alpha + TCR beta抗体[H57-597] (PE/Cy5.5 ®) (ab25682)

概述

  • 产品名称Anti-TCR alpha + TCR beta抗体[H57-597] (PE/Cy5.5 ®)
    参阅全部 TCR alpha + TCR beta 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[H57-597] to TCR alpha + TCR beta (PE/Cy5.5 ®)
  • 偶联物PE/Cy5.5 ®. Ex: 496nm, Em: 690nm
  • 特异性This antibody does not react with gamma delta TCR bearing cells.
  • 经测试应用适用于: Flow Cyt, IHC-Fr, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Full length, affinity purified, native TCR protein from mouse hybridoma DO-11.10.

  • 表位This antibody reacts with the common epitope of the beta chain of the mouse alpha beta T cell receptor complex.
  • 常规说明This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5,268,486 and related patents. Cy and CyDye are trademarks of GE Healthcare Limited.


    In vitro and in vivo, this antibody can induce immature thymocytes to undergo apoptosis. In vivo administration of this antibody has been shown to deplete alpha beta TCR bearing cells to near completion and prevent graft rejection. This antibody has also been shown to be useful in studies of 'in vitro' stimulation of alpha beta TCR expressing T cells, and 'in vitro' and 'in vivo' depletion of alpha beta bearing TCR bearing cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 16% Sucrose, PBS and stabilizing agent.
  • Concentration information loading...
  • 纯度IgG fraction
  • Primary antibody说明In vitro and in vivo, this antibody can induce immature thymocytes to undergo apoptosis. In vivo administration of this antibody has been shown to deplete alpha beta TCR bearing cells to near completion and prevent graft rejection. This antibody has also been shown to be useful in studies of 'in vitro' stimulation of alpha beta TCR expressing T cells, and 'in vitro' and 'in vivo' depletion of alpha beta bearing TCR bearing cells.
  • 克隆单克隆
  • 克隆编号H57-597
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab25682 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.2µg for 106 cells.
IHC-Fr Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

靶标

  • 相关性The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55 kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunit has, external to the cell membrane, an N terminal variable domain and a C terminal constant domain. T cell receptors recognise foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci.
  • 细胞定位Type I membrane protein.
  • 数据库链接
  • 别名
    • FLJ22602 antibody
    • MGC117436 antibody
    • MGC22624 antibody
    • MGC23964 antibody
    • MGC71411 antibody
    • T cell antigen receptor alpha polypeptide antibody
    • T cell antigen receptor beta polypeptide T cell receptor beta cluster antibody
    • T cell receptor alpha (V D J C) antibody
    • T cell receptor alpha chain C region antibody
    • T cell receptor alpha constant antibody
    • T cell receptor alpha locus antibody
    • T cell receptor beta cluster antibody
    • T cell receptor beta locus antibody
    • TCRA antibody
    • TCRB antibody
    • TCRD antibody
    • TRA antibody
    • TRAC antibody
    • TRB antibody
    see all

Anti-TCR alpha + TCR beta antibody [H57-597] (PE/Cy5.5 ®) (ab25682)参考文献

ab25682 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"