Anti-TCR alpha + TCR beta抗体[H57-597] (FITC) (ab25010)

概述

  • 产品名称
    Anti-TCR alpha + TCR beta抗体[H57-597] (FITC)
    参阅全部 TCR alpha + TCR beta 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[H57-597] to TCR alpha + TCR beta (FITC)
  • 偶联物
    FITC. Ex: 493nm, Em: 528nm
  • 特异性
    Common epitope of the ß chain of the mouse aß T cell receptor (TCR) complex.
  • 经测试应用
    适用于: Flow Cyt, IHC-Fr, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    TCR affinity purified from T-cell hybridoma DO-11.10 (Mouse)

  • 常规说明

    ab25010 can be used for in vitro stimulation of alpha beta TCR-expressing T cells and in vitro and in vivo depletion of aß TCR-bearing cells. Plate-bound or soluble ab25010 activates aß TCR bearing T cells.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C. Do Not Freeze. Store undiluted.
  • 存储溶液
    pH: 7.2
    Preservative: 0.09% Sodium azide
    Constituents: 0.14% Monobasic dihydrogen sodium phosphate, 0.87% Sodium chloride, 0.1% Gelatin
  • Concentration information loading...
  • 纯度
    Affinity purified
  • 纯化说明
    Purified from TCS
  • Primary antibody说明
    ab25010 can be used for in vitro stimulation of alpha beta TCR-expressing T cells and in vitro and in vivo depletion of aß TCR-bearing cells. Plate-bound or soluble ab25010 activates aß TCR bearing T cells.
  • 克隆
    单克隆
  • 克隆编号
    H57-597
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab25010 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
IP Use at an assay dependent concentration.

靶标

  • 相关性
    The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55 kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunit has, external to the cell membrane, an N terminal variable domain and a C terminal constant domain. T cell receptors recognise foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci.
  • 细胞定位
    Type I membrane protein.
  • 数据库链接
  • 别名
    • FLJ22602 antibody
    • MGC117436 antibody
    • MGC22624 antibody
    • MGC23964 antibody
    • MGC71411 antibody
    • T cell antigen receptor alpha polypeptide antibody
    • T cell antigen receptor beta polypeptide T cell receptor beta cluster antibody
    • T cell receptor alpha (V D J C) antibody
    • T cell receptor alpha chain C region antibody
    • T cell receptor alpha constant antibody
    • T cell receptor alpha locus antibody
    • T cell receptor beta cluster antibody
    • T cell receptor beta locus antibody
    • TCRA antibody
    • TCRB antibody
    • TCRD antibody
    • TRA antibody
    • TRAC antibody
    • TRB antibody
    see all

图片

  • Flow Cytometry analysis of C57Bl/6 splenocytes labeling TCR alpha + TCR beta with ab25010 at 0.25µg (solid line). Armenian hamster IgG (FITC) isotype control at 0.25µg (dashed line).

文献

This product has been referenced in:
  • Kubo RT  et al. Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors. J Immunol 142:2736-42 (1989). Read more (PubMed: 2467936) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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