概述

  • 产品名称Anti-Tcl1抗体
    参阅全部 Tcl1 一抗
  • 描述
    小鼠多克隆抗体to Tcl1
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human Tcl1 protein (AAH14024.1).

  • 阳性对照
    • Human spleen tissue lysate, Tcl1 transfected 293T cell line, HeLa cells.

性能

应用

Our Abpromise guarantee covers the use of ab88602 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 13 kDa.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
  • 组织特异性Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
  • 疾病相关Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
  • 序列相似性Belongs to the TCL1 family.
  • 细胞定位Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Microsomal fraction.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Anti TCL1A antibody
    • Lymphoma/leukemia, T-cell antibody
    • Oncogene TCL-1 antibody
    • Oncogene TCL1 antibody
    • P14 TCL1 antibody
    • P14 TCL1 protein antibody
    • Protein p14 TCL1 antibody
    • T cell leukemia 1 antibody
    • T cell lymphoma 1 antibody
    • T cell lymphoma 1A antibody
    • T-cell leukemia/lymphoma protein 1A antibody
    • TCL 1 protein antibody
    • TCL1 antibody
    • TCL1 oncogene antibody
    • TCL1 PEN antibody
    • Tcl1a antibody
    • TCL1A antibody antibody
    • TCL1A_HUMAN antibody
    see all

Anti-Tcl1 antibody 图像

  • Anti-Tcl1 antibody (ab88602) at 1 µg/ml + Human spleen tissue lysate at 50 µg
    Developed using the ECL technique

    Predicted band size : 13 kDa
    Observed band size : 13 kDa
  • All lanes : Anti-Tcl1 antibody (ab88602) at 1 µg/ml

    Lane 1 : cell lysate from Tcl1 transfected 293T cells
    Lane 2 : cell lysate from non transfected 293T cells

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 13 kDa
    Observed band size : ~13 kDa (why is the actual band size different from the predicted?)
  • ab88602 at 10 µg/ml detecting Tcl1 in paraformaldehyde fixed, permeabilised HeLa cells by immunofluorescence.

Anti-Tcl1 antibody (ab88602)参考文献

ab88602 has not yet been referenced specifically in any publications.

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