概述

  • 产品名称
  • 描述
    兔多克隆抗体to TCEB1
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 68-98 of Human TCEB1 (Accession: NP_005639.1).

  • 阳性对照
    • Jurkat cell line lysates.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab123730 was purified through a protein A column, followed by peptide affinity purification.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab123730 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 12 kDa.

靶标

  • 功能
    SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
    The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
  • 组织特异性
    Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.
  • 序列相似性
    Belongs to the SKP1 family.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Elo C antibody
    • EloC antibody
    • ELOC_HUMAN antibody
    • Elongin 15 kDa subunit antibody
    • Elongin C antibody
    • Elongin-C antibody
    • ElonginC antibody
    • RNA polymerase II transcription factor SIII subunit C antibody
    • SIII antibody
    • SIII p15 antibody
    • TCEB 1 antibody
    • tceb1 antibody
    • Transcription elongation factor B (SIII) polypeptide 1 antibody
    • Transcription elongation factor B polypeptide 1 antibody
    see all

图片

  • Anti-TCEB1 antibody (ab123730) at 1/100 dilution + Jurkat cell line lysates at 35 µg

    Predicted band size : 12 kDa

实验方案

文献

ab123730 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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