Anti-TCCR抗体[MM0563-8A5] (ab89745)

概述

  • 产品名称
    Anti-TCCR抗体[MM0563-8A5]
    参阅全部 TCCR 一抗
  • 描述
    小鼠单克隆抗体[MM0563-8A5] to TCCR
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human recombinant TCCR extracellular domain

  • 常规说明
    Reconstituted antibody should be aliquoted and can be stored frozen at < -20°C for at least six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

性能

应用

Our Abpromise guarantee covers the use of ab89745 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 69 kDa.

靶标

  • 功能
    Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
  • 组织特异性
    Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.
  • 序列相似性
    Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 3 fibronectin type-III domains.
  • 结构域
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Class I cytokine receptor antibody
    • CRL1 antibody
    • Cytokine receptor-like 1 antibody
    • I27RA_HUMAN antibody
    • IL-27 receptor subunit alpha antibody
    • IL-27R subunit alpha antibody
    • IL-27R-alpha antibody
    • IL-27RA antibody
    • IL27R alpha antibody
    • IL27R antibody
    • Il27ra antibody
    • Interleukin 27 receptor alpha chain precursor antibody
    • Interleukin 27 receptor antibody
    • Interleukin-27 receptor subunit alpha antibody
    • Protein CRL1 antibody
    • T cell cytokine receptor type 1 antibody
    • TCCR antibody
    • Type 1 T cell cytokine receptor antibody
    • Type I T-cell cytokine receptor antibody
    • WSX-1 antibody
    • WSX1 antibody
    • ZcytoR1 antibody
    see all

实验方案

文献

ab89745 has not yet been referenced specifically in any publications.

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