功能Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.
序列相似性Belongs to the small GTPase superfamily. Rho family.
翻译后修饰May be post-translationally modified by both palmitoylation and polyisoprenylation.
Immunohistochemistry analysis in formalin fixed and paraffin embedded Human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. ab107573 at 1/50.
Anti-TC10 antibody (ab107573)参考文献
This product has been referenced in:
Mayer S et al. Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission. Proc Natl Acad Sci U S A110:20795-800 (2013).
Read more (PubMed: 24297911) »