概述

  • 产品名称
    TC-2403 oxalate
  • 描述
    Potent α4β2 nAChR selective agonist
  • 别名
    • RJR 2403
  • 生物学描述
    High affinity α4β2 nAChR selective agonist (Ki = 26 nM). Selective for CNS nAChR over muscle, ganglionic or enteric ACh receptors (EC50 = 732 nM in rat thalamic synaptosomes).
  • 纯度
    > 99%

性能

文献

This product has been referenced in:
  • Taslim N  et al. Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) a(4)ß(2)- and a(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia. Behav Brain Res 217:282-92 (2011). Read more (PubMed: 20974182) »
  • Bodnar AL  et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem 48:905-8 (2005). Read more (PubMed: 15715459) »
  • Papke RL Enhanced inhibition of a mutant neuronal nicotinic acetylcholine receptor by agonists: protection of function by (E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403). J Pharmacol Exp Ther 301:765-73 (2002). Read more (PubMed: 11961083) »

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