The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. PubMed: 21341990
Use a concentration of 1.25 µg/ml. Predicted molecular weight: 66 kDa. Specific for isoform 3 of Tbx3. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
功能Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.
疾病相关Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.