概述

  • 产品名称Anti-TBLR1抗体
    参阅全部 TBLR1 一抗
  • 描述
    兔多克隆抗体to TBLR1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residue 100 and 150 of Human TBLR1 (Swiss-Prot Q9BZK7).

  • 阳性对照
    • Human prostate adenocarcinoma; human breast adenocarcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab84141 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
    • 组织特异性Ubiquitous.
    • 序列相似性Belongs to the WD repeat EBI family.
      Contains 1 F-box-like domain.
      Contains 1 LisH domain.
      Contains 8 WD repeats.
    • 结构域The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C21 antibody
      • DC42 antibody
      • F box like/WD repeat containing protein TBL1XR1 antibody
      • F-box-like/WD repeat-containing protein TBL1XR1 antibody
      • FLJ12894 antibody
      • IRA1 antibody
      • Nuclear receptor corepressor/HDAC3 complex subunit antibody
      • Nuclear receptor corepressor/HDAC3 complex subunit TBLR1 antibody
      • TBL1 related protein 1 antibody
      • TBL1-related protein 1 antibody
      • TBL1R_HUMAN antibody
      • TBL1XR1 antibody
      • Transducin (beta) like 1 X linked receptor 1 antibody
      • Transducin beta like 1X related protein 1 antibody
      • Transducin beta-like 1X-related protein 1 antibody
      see all

    Anti-TBLR1 antibody 图像

    • ab84141, at 1/250 dilution, staining TBLR1 in formalin-fixed, paraffin-embedded human prostate adenocarcinoma by Immunohistochemistry using DAB staining.
    • ab84141, at 1/250 dilution, staining TBLR1 in formalin-fixed, paraffin-embedded human breast adenocarcinoma by Immunohistochemistry using DAB staining.

    Anti-TBLR1 antibody (ab84141)参考文献

    ab84141 has not yet been referenced specifically in any publications.

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