Anti-TBLR1抗体[4F3-A8-D9] (ab117761)

概述

  • 产品名称Anti-TBLR1抗体[4F3-A8-D9]
    参阅全部 TBLR1 一抗
  • 描述
    小鼠单克隆抗体[4F3-A8-D9] to TBLR1
  • 经测试应用适用于: WB, ELISA, IHC-P, ICCmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant full length Human TBLR1 protein

  • 阳性对照
    • WB: K562 whole cell lysate, Mouse heart lysate, Mouse brain lysate ICC: HeLa cells IHC-P: Human breast cancer

性能

应用

Our Abpromise guarantee covers the use of ab117761 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/2000. Detects a band of approximately 60 kDa (predicted molecular weight: 56 kDa).
ELISA 1/5000 - 1/20000.
IHC-P 1/500 - 1/1000.
ICC 1/150.

靶标

  • 功能F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
  • 组织特异性Ubiquitous.
  • 序列相似性Belongs to the WD repeat EBI family.
    Contains 1 F-box-like domain.
    Contains 1 LisH domain.
    Contains 8 WD repeats.
  • 结构域The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C21 antibody
    • DC42 antibody
    • F box like/WD repeat containing protein TBL1XR1 antibody
    • F-box-like/WD repeat-containing protein TBL1XR1 antibody
    • FLJ12894 antibody
    • IRA1 antibody
    • Nuclear receptor corepressor/HDAC3 complex subunit antibody
    • Nuclear receptor corepressor/HDAC3 complex subunit TBLR1 antibody
    • TBL1 related protein 1 antibody
    • TBL1-related protein 1 antibody
    • TBL1R_HUMAN antibody
    • TBL1XR1 antibody
    • Transducin (beta) like 1 X linked receptor 1 antibody
    • Transducin beta like 1X related protein 1 antibody
    • Transducin beta-like 1X-related protein 1 antibody
    see all

Anti-TBLR1 antibody [4F3-A8-D9] 图像

  • All lanes : Anti-TBLR1 antibody [4F3-A8-D9] (ab117761) at 1/1000 dilution

    Lane 1 : Mouse Brain Lysate
    Lane 2 : Mouse Heart Lysate
    Lane 3 : K562 cell Lysate


    Predicted band size : 56 kDa
  • ab117761, at 1/500 - 1/1000 dilution, staining TBLR1 in paraffin-embedded Human breast cancer by Imunohistochemistry.
  • ab117761, at 1/150 dilution, staining TBLR1 in HeLa cells by Immunocytochemistry.
  • Immunocytochemical staining of HeLa cells using anti-TBLR1 antibody (ab117761) at a dilution of 1:200. Cells were fixed with 4% paraformaldehyde.

  • Anti-TBLR1 antibody [4F3-A8-D9] (ab117761) at 1/1000 dilution + K562 whole cell lysate at 40 µg

    Predicted band size : 56 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-TBLR1 antibody [4F3-A8-D9] (ab117761) at 1/1000 dilution

    Lane 1 : Mouse heart lysate
    Lane 2 : Mouse brain lysate

    Lysates/proteins at 40 µg per lane.


    Predicted band size : 56 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)

Anti-TBLR1 antibody [4F3-A8-D9] (ab117761)参考文献

ab117761 has not yet been referenced specifically in any publications.

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