概述

  • 产品名称Anti-TBL1抗体
    参阅全部 TBL1 一抗
  • 描述
    山羊多克隆抗体to TBL1
  • 特异性This antibody is also expected to recognise the human protein TBLR1 (NP_078941), which is very similar.
  • 经测试应用适用于: IHC, ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide corresponding to Human TBL1 aa 564-577 (C terminal).
    Sequence:

    SASDGSVCVLDLRK


    Database link: O60907
    (Peptide available as ab22881)

  • 常规说明Principal Names - TBL1X; transducin (beta)-like 1X-linked; EBI; TBL1; transducin (beta)-like 1; transducin (beta)-like 1 X-linked. Official Gene Symbol - TBL1X. GenBank Accession Number – NP_005638. LocusLink ID - 6907.

性能

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应用

Our Abpromise guarantee covers the use of ab2243 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC Use a concentration of 4 - 6 µg/ml.
ELISA Use at an assay dependent concentration.

Antibody detection limit dilution 1:4,000.

WB Use a concentration of 3 - 5 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 58 kDa).Can be blocked with Human TBL1 peptide (ab22881).

靶标

  • 功能F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
  • 组织特异性Ubiquitous.
  • 序列相似性Belongs to the WD repeat EBI family.
    Contains 1 F-box-like domain.
    Contains 1 LisH domain.
    Contains 8 WD repeats.
  • 结构域The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EBI antibody
    • F box like/WD repeat protein TBL1X antibody
    • F-box-like/WD repeat-containing protein TBL1X antibody
    • SMAP 55 antibody
    • SMAP55 antibody
    • TBL 1 antibody
    • TBL 1X antibody
    • TBL1 antibody
    • TBL1X antibody
    • TBL1X_HUMAN antibody
    • Transducin (beta) like 1 antibody
    • Transducin (beta) like 1 X linked antibody
    • Transducin (beta) like 1X linked antibody
    • Transducin beta like 1 X linked antibody
    • Transducin beta like 1X antibody
    • Transducin beta like 1X protein antibody
    • Transducin beta like protein 1, X linked antibody
    • Transducin beta-like protein 1X antibody
    • Transducin-beta-like protein 1 antibody
    • X-linked antibody
    see all

Anti-TBL1 antibody 图像

  • Immunohistochemical analysis of paraffin embedded Human Kidney tissue labeling TBL1 with ab5642 at 4 ug/ml. Tissue underwent antigen retrieval in steam with Tris/EDTA buffer (pH 9.0). The HRP-staining procedure was used for detection.



  • Predicted band size : 58 kDa
    ab2243 staining (4µg/ml) of Human Brain lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. ab2243 staining (4µg/ml) of Human Brain lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Anti-TBL1 antibody (ab2243)参考文献

This product has been referenced in:
  • Hoberg JE  et al. SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival. Mol Cell 16:245-55 (2004). Read more (PubMed: 15494311) »

See 1 Publication for this product

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