概述

  • 产品名称
  • 描述
    小鼠多克隆抗体to TBCD
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human TBCD protein (AAH39654)

  • 阳性对照
    • TBCD transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab72624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 75 kDa (predicted molecular weight: 133 kDa).

靶标

  • 功能
    Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.
  • 组织特异性
    Ubiquitously expressed.
  • 序列相似性
    Belongs to the TBCD family.
    Contains 3 HEAT repeats.
  • 细胞定位
    Cell junction > tight junction. Lateral cell membrane. Cytoplasm. Cell junction > adherens junction. Localized in cell-cell contacts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beta tubulin cofactor D antibody
    • Beta-tubulin cofactor D antibody
    • KIAA0988 antibody
    • SSD 1 antibody
    • SSD-1 antibody
    • SSD1 antibody
    • tbcd antibody
    • TBCD_HUMAN antibody
    • tfcD antibody
    • Tubulin folding cofactor D antibody
    • Tubulin specific chaperone D antibody
    • Tubulin-folding cofactor D antibody
    • Tubulin-specific chaperone D antibody
    see all

图片

  • All lanes : Anti-TBCD antibody (ab72624) at 1/500 dilution

    Lane 1 : TBCD transfected 293T cell lystae
    Lane 2 : Non transfected 293T cell lystae

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG(H&L)-HRP Conjugate at 1/25000 dilution

    Predicted band size : 133 kDa
    Observed band size : 75 kDa (why is the actual band size different from the predicted?)

实验方案

文献

ab72624 has not yet been referenced specifically in any publications.

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