概述

  • 产品名称Anti-TBCD抗体
    参阅全部 TBCD 一抗
  • 描述
    兔多克隆抗体to TBCD
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, corresponding to a region within internal sequence amino acids 299-348 (KLVQRLGLTF LKPKVAAWRY QRGCRSLAAN LQLLTQGQSE QKPLILTEDD) of Human TBCD (NM_005993).

  • 阳性对照
    • HeLa cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab116519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 133 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.
  • 组织特异性Ubiquitously expressed.
  • 序列相似性Belongs to the TBCD family.
    Contains 3 HEAT repeats.
  • 细胞定位Cell junction > tight junction. Lateral cell membrane. Cytoplasm. Cell junction > adherens junction. Localized in cell-cell contacts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beta tubulin cofactor D antibody
    • Beta-tubulin cofactor D antibody
    • KIAA0988 antibody
    • SSD 1 antibody
    • SSD-1 antibody
    • SSD1 antibody
    • tbcd antibody
    • TBCD_HUMAN antibody
    • tfcD antibody
    • Tubulin folding cofactor D antibody
    • Tubulin specific chaperone D antibody
    • Tubulin-folding cofactor D antibody
    • Tubulin-specific chaperone D antibody
    see all

Anti-TBCD antibody 图像

  • Anti-TBCD antibody (ab116519) at 1 µg/ml + HeLa cell lysate at 10 µg

    Predicted band size : 133 kDa

Anti-TBCD antibody (ab116519)参考文献

ab116519 has not yet been referenced specifically in any publications.

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