Anti-Tau 13抗体[B11E8] (ab19030)

概述

  • 产品名称Anti-Tau 13抗体[B11E8]
  • 描述
    小鼠单克隆抗体[B11E8] to Tau 13
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to the N-terminus of human Tau.

  • 常规说明


    The antibody recognizes 45-60 kDa isoform of human Tau-13.

性能

应用

Our Abpromise guarantee covers the use of ab19030 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 79 kDa.
IP 1/500.

靶标

  • 相关性Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF)and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK 3 beta, PKA, Cdk 5, and casein kinase II can phosphorylate tau.
  • 细胞定位Cytoplasmic and Plasma membrane
  • 数据库链接
  • 别名
    • FTDP17 antibody
    • Microtubule associated protein tau antibody
    • Paired helical filament tau antibody
    • PHF tau antibody
    • PPND antibody
    • TAU antibody
    see all

Anti-Tau 13 antibody [B11E8] (ab19030)参考文献

ab19030 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Sample Human Cell lysate - whole cell (iPSC-derived neuronal culture)
Gel Running Conditions Reduced Denaturing (4-20% gel)
Loading amount 2.5 µg
Specification iPSC-derived neuronal culture
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C
Username

Dr. Martin Engel

Verified customer

提交于 Nov 02 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"