Anti-TAPA1抗体[Eat 2] (Phycoerythrin) (ab23553)

概述

  • 产品名称Anti-TAPA1抗体[Eat 2] (Phycoerythrin)
    参阅全部 TAPA1 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[Eat 2] to TAPA1 (Phycoerythrin)
  • 偶联物Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特异性ab23553 recognises CD81, a 26kD cell surface glycoprotein that is also known as TAPA-1.
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Tissue/ cell preparation: 38C13, murine B cell line.

  • 常规说明Myeloma: Spleen cells from immunised Armenian hamsters were fused with cells of the mouse PX3-Ag.8.653 myeloma cell line.

    Purified IgG conjugated to R. Phycoerythrin (RPE).

性能

应用

Our Abpromise guarantee covers the use of ab23553 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
  • 应用说明Flow Cyt: 1/neat.
    Use 10µl for 106 cells in 100µl.

    Note: ab23553 induces homotypic aggregation of B cells and inhibits anti Ig and IL4 induced proliferation. ab23553 requires the presence of both extracellular loops of TAPA1 for binding.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV.
    • 组织特异性Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
    • 疾病相关Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
    • 序列相似性Belongs to the tetraspanin (TM4SF) family.
    • 翻译后修饰Not glycosylated.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 26 kDa cell surface protein TAPA 1 antibody
      • 26 kDa cell surface protein TAPA-1 antibody
      • 26 kDa cell surface protein TAPA1 antibody
      • CD 81 antibody
      • CD81 antibody
      • CD81 antigen (target of antiproliferative antibody 1) antibody
      • CD81 antigen antibody
      • CD81 molecule antibody
      • CD81_HUMAN antibody
      • CVID6 antibody
      • S5.7 antibody
      • TAPA 1 antibody
      • TAPA1 antibody
      • Target of the antiproliferative antibody 1 antibody
      • Tetraspanin 28 antibody
      • Tetraspanin-28 antibody
      • Tetraspanin28 antibody
      • Tspan 28 antibody
      • Tspan-28 antibody
      • Tspan28 antibody
      see all

    Anti-TAPA1 antibody [Eat 2] (Phycoerythrin) (ab23553)参考文献

    ab23553 has not yet been referenced specifically in any publications.

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