PE Anti-CD81抗体[Eat 2] (ab23553)
Key features and details
- PE Armenian hamster monoclonal [Eat 2] to CD81
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG
概述
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产品名称
PE Anti-CD81抗体[Eat 2]
参阅全部 CD81 一抗 -
描述
PE亚美尼亚仓鼠单克隆抗体[Eat 2] to CD81 -
宿主
Armenian hamster -
偶联物
PE. Ex: 488nm, Em: 575nm -
特异性
ab23553 recognises CD81, a 26kD cell surface glycoprotein that is also known as TAPA-1. -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Flow Cyt: Mouse blood
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常规说明
Myeloma: Spleen cells from immunised Armenian hamsters were fused with cells of the mouse PX3-Ag.8.653 myeloma cell line.Purified IgG conjugated to R. Phycoerythrin (RPE).
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
Eat 2 -
同种型
IgG -
研究领域
相关产品
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab23553于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
说明 |
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Use 10µl for 106 cells in 100µl.
Note: ab23553 induces homotypic aggregation of B cells and inhibits anti Ig and IL4 induced proliferation. ab23553 requires the presence of both extracellular loops of TAPA1 for binding.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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功能
May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV. -
组织特异性
Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines. -
疾病相关
Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. -
序列相似性
Belongs to the tetraspanin (TM4SF) family. -
翻译后修饰
Not glycosylated. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 12520 Mouse
- SwissProt: P35762 Mouse
- Unigene: 806 Mouse
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别名
- 26 kDa cell surface protein TAPA 1 antibody
- 26 kDa cell surface protein TAPA-1 antibody
- 26 kDa cell surface protein TAPA1 antibody
see all
图片
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Flow cytometric analysis of mouse blood labelling CD81 with ab23553 at 1/10 dilution (Right). Compared with Alexa Fluor® 700 conjugated hamster IgG1 isotype control (Left). Gated on live, single lymphocytes in the presence of 10% mouse serum. Cells were stained with Alexa Fluor 700 conjugated Rat anti Mouse CD19. Data acquired on the ZE5™ Cell Analyzer.
数据表及文件
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Datasheet download
文献 (0)
ab23553 尚未被引用在任何文献中。