概述

  • 产品名称
    Anti-TAPA1抗体[Eat 2]
    参阅全部 TAPA1 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[Eat 2] to TAPA1
  • 特异性
    ab33697 recognises mouse and rat TAPA1. In rodents TAPA1is expressed at much higher levels on resting B cells than on T cells, although increased expression on T cells is found following activation.
  • 经测试应用
    适用于: Flow Cyt, IHC-Fr, ELISA, IP, WB, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Murine B cell line (38C13).

  • 表位
    extracellular loops of TAPA-1
  • 阳性对照
    • B cells.
  • 常规说明
    This antibody was raised in Armenian hamster.


    ab33697 induces homotypic aggregation of B cells and inhibits anti Ig and IL-4 induced proliferation. ab33697 requires the presence of both extracellular loops of TAPA-1 for binding. Not suitable for IHC-P.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度
    Protein G purified
  • Primary antibody说明
    ab33697 induces homotypic aggregation of B cells and inhibits anti Ig and IL-4 induced proliferation. ab33697 requires the presence of both extracellular loops of TAPA-1 for binding. Not suitable for IHC-P.
  • 克隆
    单克隆
  • 克隆编号
    Eat 2
  • 骨髓瘤
    P3x63-Ag8.653
  • 同种型
    IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab33697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt 1/50 - 1/100.
IHC-Fr Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.
IP Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 26 kDa.
ICC/IF Use at an assay dependent concentration. PubMed: 21600883

靶标

  • 功能
    May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV.
  • 组织特异性
    Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
  • 疾病相关
    Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • 序列相似性
    Belongs to the tetraspanin (TM4SF) family.
  • 翻译后修饰
    Not glycosylated.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 26 kDa cell surface protein TAPA 1 antibody
    • 26 kDa cell surface protein TAPA-1 antibody
    • 26 kDa cell surface protein TAPA1 antibody
    • CD 81 antibody
    • CD81 antibody
    • CD81 antigen (target of antiproliferative antibody 1) antibody
    • CD81 antigen antibody
    • CD81 molecule antibody
    • CD81_HUMAN antibody
    • CVID6 antibody
    • S5.7 antibody
    • TAPA 1 antibody
    • TAPA1 antibody
    • Target of the antiproliferative antibody 1 antibody
    • Tetraspanin 28 antibody
    • Tetraspanin-28 antibody
    • Tetraspanin28 antibody
    • Tspan 28 antibody
    • Tspan-28 antibody
    • Tspan28 antibody
    see all

文献

This product has been referenced in:
  • Hanagata N & Li X Osteoblast-enriched membrane protein IFITM5 regulates the association of CD9 with an FKBP11-CD81-FPRP complex and stimulates expression of interferon-induced genes. Biochem Biophys Res Commun 409:378-84 (2011). WB, ICC/IF ; Rat . Read more (PubMed: 21600883) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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