Anti-TAPA1抗体[1D6] (ab23505)


  • 产品名称Anti-TAPA1抗体[1D6]
    参阅全部 TAPA1 一抗
  • 描述
    小鼠单克隆抗体[1D6] to TAPA1
  • 特异性ab23505 recognises human CD81, a 26kD cell surface antigen also known as TAPA-1, and a member of the tetraspanin family.
  • 经测试应用适用于: Flow Cyt, IHC-P, IP, ICC/IFmore details
    不适用于: WB
  • 种属反应性
    与反应: Human, Chimpanzee
  • 免疫原

    Aggregated OCI-LY8 cells (Human).

  • 常规说明

    This antibody induces homotypic adhesion and has powerful anti proliferative effects.



Our Abpromise guarantee covers the use of ab23505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IHC-P Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV.
    • 组织特异性Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
    • 疾病相关Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
    • 序列相似性Belongs to the tetraspanin (TM4SF) family.
    • 翻译后修饰Not glycosylated.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 26 kDa cell surface protein TAPA 1 antibody
      • 26 kDa cell surface protein TAPA-1 antibody
      • 26 kDa cell surface protein TAPA1 antibody
      • CD 81 antibody
      • CD81 antibody
      • CD81 antigen (target of antiproliferative antibody 1) antibody
      • CD81 antigen antibody
      • CD81 molecule antibody
      • CD81_HUMAN antibody
      • CVID6 antibody
      • S5.7 antibody
      • TAPA 1 antibody
      • TAPA1 antibody
      • Target of the antiproliferative antibody 1 antibody
      • Tetraspanin 28 antibody
      • Tetraspanin-28 antibody
      • Tetraspanin28 antibody
      • Tspan 28 antibody
      • Tspan-28 antibody
      • Tspan28 antibody
      see all

    Anti-TAPA1 antibody [1D6] (ab23505)参考文献

    This product has been referenced in:
    • Christianson HC  et al. Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity. Proc Natl Acad Sci U S A 110:17380-5 (2013). WB ; Human . Read more (PubMed: 24101524) »
    • Wang AL  et al. Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS One 4:e4160 (2009). Flow Cyt ; Human . Read more (PubMed: 19129916) »

    See all 2 Publications for this product

    Product Wall

    Application Western blot
    Sample Human Cell lysate - whole cell (gastric)
    Loading amount 20 µg
    Specification gastric
    Gel Running Conditions Non-reduced Denaturing (4-12%)
    Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C

    Abcam user community

    Verified customer

    提交于 May 19 2009

    Thank you for your enquiry. I am sorry to hear that you have been having difficulties with this antibody. I am sorry but the expression of Tapa1 is outside of my area of expertese. I would appreciate it if you could explain to me why you are attempt...

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