Anti-Tankyrase 2抗体(ab92329)


  • 产品名称Anti-Tankyrase 2抗体
    参阅全部 Tankyrase 2 一抗
  • 描述
    山羊多克隆抗体to Tankyrase 2
  • 特异性No crossreactivity expected with Tankyrase 1.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Dog
  • 免疫原

    Fusion protein containing 73 amino acids from the 800-900 amino acid region of Human Tankyrase 2 (NP_079511.1).

  • 阳性对照
    • HEK293 overexpressing Tankyrase 2



Our Abpromise guarantee covers the use of ab92329 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 127 kDa (predicted molecular weight: 127 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
    • 组织特异性Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.
    • 序列相似性Contains 15 ANK repeats.
      Contains 1 PARP catalytic domain.
      Contains 1 SAM (sterile alpha motif) domain.
    • 翻译后修饰Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation.
      ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
      The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.
    • 细胞定位Cytoplasm. Golgi apparatus membrane. Nucleus. Chromosome > telomere. Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ADP-ribosyltransferase diphtheria toxin-like 6 antibody
      • ARTD6 antibody
      • PARP 5b antibody
      • PARP 5c antibody
      • PARP-5b antibody
      • PARP-5c antibody
      • PARP5B antibody
      • PARP5C antibody
      • pART6 antibody
      • Poly [ADP ribose] polymerase 5B antibody
      • Poly [ADP-ribose] polymerase 5B antibody
      • TANK2 antibody
      • Tankyrase 2 antibody
      • Tankyrase II antibody
      • Tankyrase like protein antibody
      • Tankyrase related protein antibody
      • Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2 antibody
      • Tankyrase-2 antibody
      • Tankyrase-like protein antibody
      • Tankyrase-related protein antibody
      • TNKL antibody
      • TNKS 2 antibody
      • TNKS-2 antibody
      • TNKS2 antibody
      • TNKS2_HUMAN antibody
      • TRF1 Interacting Ankyrin Related ADP ribose polymerase 2 antibody
      • TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antibody
      see all

    Anti-Tankyrase 2 antibody 图像

    • All lanes : Anti-Tankyrase 2 antibody (ab92329) at 0.5 µg/ml

      Lane 1 : Mock transfection
      Lane 2 : HEK293 overexpressing Tankyrase 1
      Lane 3 : HEK293 overexpressing Tankyrase 2

      Developed using the ECL technique

      Predicted band size : 127 kDa
      Observed band size : 127 kDa

    Anti-Tankyrase 2 antibody (ab92329)参考文献

    ab92329 has not yet been referenced specifically in any publications.

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