概述

  • 产品名称
    Tamoxifen citrate
  • 描述
    Estrogen receptor拮抗剂and partial激动剂
  • 生物学描述
    Competitive estrogen receptor antagonist and partial agonist. Inhibits estrogen dependent gene transcription and tumor growth. Additionally decreases cardiac infarction and inhibits Kir2.1, Kir2.2 and Kir2.3 potassium channels (IC50 values are 0.93, 0.87 and 0.31 µM, respectively).
  • 纯度
    > 99%

性能

文献

This product has been referenced in:
  • Ponce-Balbuena D  et al. Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions. J Pharmacol Exp Ther 331:563-73 (2009). Read more (PubMed: 19654266) »
  • Massarweh S  et al. Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Res 68:826-33 (2008). Read more (PubMed: 18245484) »
  • Mandlekar S & Kong AN Mechanisms of tamoxifen-induced apoptosis. Apoptosis 6:469-77 (2001). Read more (PubMed: 11595837) »

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