概述

  • 产品名称Anti-Tal1抗体
    参阅全部 Tal1 一抗
  • 描述
    兔多克隆抗体to Tal1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (Human) corresponding to amino acid residues surrounding T90, conjugated to KLH.

  • 阳性对照
    • Jurkat cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab75738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Predicted molecular weight: 34 kDa.
ELISA 1/1000.

靶标

  • 功能Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
  • 组织特异性Leukemic stem cell.
  • 疾病相关Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
  • 序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
  • 结构域The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
  • 翻译后修饰Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.
    Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • bHLHa17 antibody
    • Class A basic helix-loop-helix protein 17 antibody
    • OTTHUMP00000009563 antibody
    • OTTHUMP00000009564 antibody
    • SCL antibody
    • STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR antibody
    • Stem cell protein antibody
    • T cell acute lymphocytic leukemia 1 antibody
    • T cell acute lymphocytic leukemia 1 protein antibody
    • T cell acute lymphocytic leukemia 1 protein antibody
    • T cell leukemia/lymphoma 5 protein antibody
    • T-cell acute lymphocytic leukemia protein 1 antibody
    • T-cell leukemia/lymphoma protein 5 antibody
    • Tal 1 antibody
    • Tal 1 product antibody
    • TAL 1 protein antibody
    • TAL-1 antibody
    • tal1 antibody
    • TAL1_HUMAN antibody
    • TCL 5 antibody
    • TCL5 antibody
    see all

Anti-Tal1 antibody 图像

Anti-Tal1 antibody (ab75738)参考文献

This product has been referenced in:
  • Kolodziej S  et al. PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation. Nat Commun 5:3995 (2014). ChIP ; Human . Read more (PubMed: 24874575) »

See 1 Publication for this product

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