Anti-TACI抗体[MM0562-9D22] (ab89744)
Key features and details
- Mouse monoclonal [MM0562-9D22] to TACI
- Suitable for: IHC-Fr, WB, Neutralising
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-TACI抗体[MM0562-9D22]
参阅全部 TACI 一抗 -
描述
小鼠单克隆抗体[MM0562-9D22] to TACI -
宿主
Mouse -
经测试应用
适用于: IHC-Fr, WB, Neutralisingmore details -
种属反应性
与反应: Human -
免疫原
Human recombinant TACI extracellular domain
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常规说明
Reconstituted antibody should be aliquoted and can be stored frozen at < -20°C for at least six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Reconstitute with 200 µl sterile PBS to give a final concentration of 0.5 mg/ml. -
存放说明
Shipped at 4°C. Store at -80°C. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter. -
克隆
单克隆 -
克隆编号
MM0562-9D22 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab89744于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-Fr |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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Neutralising |
Use at an assay dependent concentration.
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说明 |
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IHC-Fr
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Neutralising
Use at an assay dependent concentration. |
靶标
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功能
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. -
组织特异性
Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells. -
疾病相关
Defects in TNFRSF13B are the cause of immunodeficiency common variable type 2 (CVID2) [MIM:240500]. CVID2 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Defects in TNFRSF13B are a cause of immunoglobulin A deficiency 2 (IGAD2) [MIM:609529]. Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology. -
序列相似性
Contains 2 TNFR-Cys repeats. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 23495 Human
- Omim: 604907 Human
- SwissProt: O14836 Human
- Unigene: 158341 Human
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别名
- CD 267 antibody
- CD267 antibody
- CD267 antigen antibody
see all
数据表及文件
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Datasheet download
文献 (0)
ab89744 尚未被引用在任何文献中。