概述

  • 产品名称Anti-TACI抗体(Biotin)
    参阅全部 TACI 一抗
  • 描述
    山羊多克隆抗体to TACI (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: ELISA, Sandwich ELISA, WB, IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Highly pure (>98%) recombinant human TACI

  • 常规说明ab83515 is sterile filtered.

性能

  • 形式Lyophilised:Centrifuge vial prior to opening. Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab83515 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
Sandwich ELISA
WB
IP
  • 应用说明ELISA: Use at a concentration of 0.25 - 1 µg/ml. Allows the detection of at least 0.2 - 0.4 ng/well of recombinant human TACI.
    sELISA: Use at a concentration of 0.25 - 1 µg/ml. Allows the detection of at least 0.2 - 0.4 ng/well of recombinant human TACI.
    WB: Use at a concentration of 0.1 - 0.2 µg/ml. The detection limit for recombinant human TACI is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions. Predicted molecular weight: 32 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
    • 组织特异性Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells.
    • 疾病相关Defects in TNFRSF13B are the cause of immunodeficiency common variable type 2 (CVID2) [MIM:240500]. CVID2 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
      Defects in TNFRSF13B are a cause of immunoglobulin A deficiency 2 (IGAD2) [MIM:609529]. Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology.
    • 序列相似性Contains 2 TNFR-Cys repeats.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD 267 antibody
      • CD267 antibody
      • CD267 antigen antibody
      • CVID antibody
      • CVID2 antibody
      • FLJ39942 antibody
      • MGC133214 antibody
      • MGC39952 antibody
      • OTTHUMP00000065442 antibody
      • TNFRSF 13B antibody
      • TNFRSF 14B antibody
      • TNFRSF13B antibody
      • TNFRSF13B protein antibody
      • TNFRSF14B antibody
      • TR13B_HUMAN antibody
      • Transmembrane activator and CAML interactor antibody
      • Tumor necrosis factor receptor 13B antibody
      • Tumor necrosis factor receptor superfamily member 13B antibody
      see all

    Anti-TACI antibody (Biotin) (ab83515)参考文献

    This product has been referenced in:
    • Romberg N  et al. CVID-associated TACI mutations affect autoreactive B cell selection and activation. J Clin Invest 123:4283-93 (2013). IP ; Human . Read more (PubMed: 24051380) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab83515.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"