Anti-TACI抗体(ab79023)

概述

  • 产品名称Anti-TACI抗体
    参阅全部 TACI 一抗
  • 描述
    兔多克隆抗体to TACI
  • 经测试应用适用于: WB, IHC-P, Flow Cytmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Chimpanzee
  • 免疫原

    Synthetic peptide:

    PELRRQRSGEVENNSDN

    , corresponding to amino acids 116-132 of Human TACI

  • 阳性对照
    • Spleen tissue.

性能

应用

Our Abpromise guarantee covers the use of ab79023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
Flow Cyt
  • 应用说明Flow Cyt: Use at an assay dependent dilution.
    IHC-P: Use at a concentration of 5 µg/ml.
    WB: Use at a concentration of 5 µg/ml. Predicted molecular weight: 32 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
    • 组织特异性Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells.
    • 疾病相关Defects in TNFRSF13B are the cause of immunodeficiency common variable type 2 (CVID2) [MIM:240500]. CVID2 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
      Defects in TNFRSF13B are a cause of immunoglobulin A deficiency 2 (IGAD2) [MIM:609529]. Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology.
    • 序列相似性Contains 2 TNFR-Cys repeats.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD 267 antibody
      • CD267 antibody
      • CD267 antigen antibody
      • CVID antibody
      • CVID2 antibody
      • FLJ39942 antibody
      • MGC133214 antibody
      • MGC39952 antibody
      • OTTHUMP00000065442 antibody
      • TNFRSF 13B antibody
      • TNFRSF 14B antibody
      • TNFRSF13B antibody
      • TNFRSF13B protein antibody
      • TNFRSF14B antibody
      • TR13B_HUMAN antibody
      • Transmembrane activator and CAML interactor antibody
      • Tumor necrosis factor receptor 13B antibody
      • Tumor necrosis factor receptor superfamily member 13B antibody
      see all

    Anti-TACI antibody 图像

    • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue, staining TACI with ab79023 at 5 µg/ml.
    • Anti-TACI antibody (ab79023) at 0.1 µg/ml + Daudi cell lysate at 10 µg

      Predicted band size : 32 kDa

    Anti-TACI antibody (ab79023)参考文献

    ab79023 has not yet been referenced specifically in any publications.

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