概述

性能

应用

Our Abpromise guarantee covers the use of ab17915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP
WB
  • 应用说明IP: Use at an assay dependent dilution.
    WB: Use at a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 125 and 55 kDa (predicted molecular weight: 90 kDa, there are several other isoforms).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
    • 组织特异性Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.
    • 序列相似性Belongs to the TACC family.
      Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.
    • 发展阶段Expressed at high level during early embryogenesis.
    • 翻译后修饰Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome. Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DKFZp686K18126 antibody
      • Ga 55 antibody
      • Ga55 antibody
      • Gastric cancer antigen Ga 55 antibody
      • Gastric cancer antigen Ga55 antibody
      • KIAA1103 antibody
      • TACC 1 antibody
      • Tacc1 antibody
      • TACC1_HUMAN antibody
      • Taxin 1 antibody
      • Taxin-1 antibody
      • Taxin1 antibody
      • Transforming acidic coiled coil containing protein 1 antibody
      • Transforming acidic coiled-coil-containing protein 1 antibody
      see all

    Anti-TACC1 antibody (ab17915)参考文献

    ab17915 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"