Potent, selective PPARγ antagonist (IC50 = 1 nM). Antidiabetic actions in vivo. Inhibits rosiglitazone (ab120762). Blocks the recruitment of transcriptional cofactors to the PPARγ/RXR heterodimer.
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Schaefer KL et al. Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Cancer Res65:2251-9 (2005).
Read more (PubMed: 15781638) »
Rockwell CE & Kaminski NE A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J Pharmacol Exp Ther311:683-90 (2004).
Read more (PubMed: 15284281) »
Lee G et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem277:19649-57 (2002).
Read more (PubMed: 11877444) »