概述

  • 产品名称Anti-T-bet / Tbx21抗体
    参阅全部 T-bet / Tbx21 一抗
  • 描述
    小鼠单克隆抗体to T-bet / Tbx21
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Horse, Cow, Dog, Chimpanzee, Macaque Monkey
  • 免疫原

    Recombinant fragment: LGAPRDHSYE AEFRAVSMKP AFLPSAPGPT MSYYRGQEVL APGAGWPVAP QYPPKMGPAS WFRPMRTLPM EPGPGGSEGR GPEDQGPPLV WTEIAPIRPE , corresponding to amino acids 387-486 of Human T-bet/ Tbx21 (AAH39739) with a proprietary tag

  • 阳性对照
    • NIH 3T3 cell lysate

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab88114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 58 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.
  • 组织特异性T-cell specific.
  • 疾病相关Genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]. A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.
  • 序列相似性Contains 1 T-box DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • T bet antibody
    • T box 21 antibody
    • T box expressed in T cells antibody
    • T box protein 21 antibody
    • T box transcription factor TBX21 antibody
    • T cell specific T box transcription factor antibody
    • T cell specific T box transcription factor T bet antibody
    • T PET antibody
    • T-box protein 21 antibody
    • T-box transcription factor TBX21 antibody
    • T-cell-specific T-box transcription factor T-bet antibody
    • TBET antibody
    • TBLYM antibody
    • TBX 21 antibody
    • Tbx21 antibody
    • TBX21_HUMAN antibody
    • TPET antibody
    • Transcription factor TBLYM antibody
    see all

Anti-T-bet / Tbx21 antibody 图像

  • Anti-T-bet / Tbx21 antibody (ab88114) at 1 µg/ml + immunogen (tagged recombinant fragment) at 0.2 µg

    Secondary
    Goat anti-Mouse IgG at 1/5000 dilution

    Predicted band size : 58 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
  • Anti-T-bet / Tbx21 antibody (ab88114) at 1 µg/ml + NIH 3T3 cell lysate at 25 µg

    Secondary
    Goat anti-Mouse IgG at 1/5000 dilution

    Predicted band size : 58 kDa

Anti-T-bet / Tbx21 antibody (ab88114)参考文献

This product has been referenced in:
  • Singh SP  et al. Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation. J Immunol 187:4542-52 (2011). WB ; Mouse . Read more (PubMed: 21930963) »
  • Yang P  et al. The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers. Int J Immunogenet 37:111-5 (2010). Read more (PubMed: 20193034) »

See all 2 Publications for this product

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