概述

  • 产品名称Anti-SYVN1抗体
    参阅全部 SYVN1 一抗
  • 描述
    兔多克隆抗体to SYVN1
  • 经测试应用适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, from the C-terminal region of Human SYVN1 (NP_115807.1).

  • 阳性对照
    • Human kidney and liver tissues; T47D cell and Mouse kidney tissue lysates.

性能

应用

Our Abpromise guarantee covers the use of ab118483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 67 kDa.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ELISA 1/1000.

靶标

  • 功能Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
  • 组织特异性Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level).
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the HRD1 family.
    Contains 1 RING-type zinc finger.
  • 结构域The RING-type zinc finger is required for E3 ligase activity.
  • 翻译后修饰Not N-glycosylated.
    Auto-ubiquitinated.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1200010C09Rik antibody
    • DER3 antibody
    • E3 ubiquitin-protein ligase synoviolin antibody
    • HMG coA reductase degradation 1 homolog antibody
    • HRD1 antibody
    • KIAA1810 antibody
    • MGC40372 antibody
    • OTTHUMP00000230429 antibody
    • OTTHUMP00000230430 antibody
    • OTTHUMP00000230431 antibody
    • OTTHUMP00000230432 antibody
    • Synovial apoptosis inhibitor 1 antibody
    • Synovial apoptosis inhibitor 1, synoviolin antibody
    • Synoviolin 1 isoform b antibody
    • SYNOVIOLIN antibody
    • SYVN1 antibody
    • SYVN1_HUMAN antibody
    see all

Anti-SYVN1 antibody 图像

  • ab118483 at 10µg/ml staining SYVN1 in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab118483 at 10µg/ml staining SYVN1 in Formalin-fixed, Paraffin-embedded Human liver tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Anti-SYVN1 antibody (ab118483) at 1/100 dilution + T47D cell lysate at 35 µg

    Predicted band size : 67 kDa
  • Anti-SYVN1 antibody (ab118483) at 1/100 dilution + Mouse kidney tissue lysate

    Predicted band size : 67 kDa

Anti-SYVN1 antibody (ab118483)参考文献

ab118483 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab118483.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"