The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明WB: Use at a concentration of 1-5 µg/ml.
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
功能May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
序列相似性Belongs to the synaptotagmin family. Contains 2 C2 domains.
翻译后修饰Ubiquitinated and targeted to the proteasome complex for degradation.
细胞定位Membrane. Cell junction > synapse. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.