概述
- 产品名称Anti-Syntaxin 1a抗体[SP36]
参阅全部 Syntaxin 1a 一抗 - 描述兔单克隆抗体[SP36] to Syntaxin 1a
- 经测试应用适用于: IHC-Pmore details
- 种属反应性与反应: Human
- 免疫原
Synthetic peptide corresponding to N terminus of human Syntaxin 1a
- 表位N terminus
- 阳性对照
- Human brain tissue
性能
- 形式Liquid
- 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- 存储溶液Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 10mM PBS, pH 7.4 -
Concentration information loading... - 纯度IgG fraction
- 纯化说明Purified IgG
- 克隆单克隆
- 克隆编号SP36
- 同种型IgG
- 研究领域
应用
Our Abpromise guarantee covers the use of ab73913 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes, followed by cooling at room temperature for 20 minutes.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
- 功能Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
- 组织特异性Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
- 疾病相关Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
- 序列相似性Belongs to the syntaxin family.
Contains 1 t-SNARE coiled-coil homology domain. - 细胞定位Secreted and Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.
- Information by UniProt
-
数据库链接
- Entrez Gene: 6804 Human
- Omim: 186590 Human
- SwissProt: Q16623 Human
- Unigene: 647024 Human
-
别名
- HPC 1 antibody
- Neuron specific antigen HPC1 antibody
- Neuron-specific antigen HPC-1 antibody
see all
Anti-Syntaxin 1a antibody [SP36] 图像
-
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Syntaxin 1a antibody [SP36] (ab73913)](http://www.abcam.cn/ps/datasheet/Images/73/ab73913/ab73913_IHC2.JPG)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Syntaxin 1a antibody [SP36] (ab73913)ab73913, at a 1/100 dilution, staining Syntaxin 1a in formalin fixed, paraffin embedded human brain tissue by Immunohistochemistry.
Anti-Syntaxin 1a antibody [SP36] (ab73913)参考文献
ab73913 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"