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RabMAb

Anti-Syntaxin 1a抗体[SP36] (ab73913)

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概述

  • 产品名称
    Anti-Syntaxin 1a抗体[SP36]
    参阅全部 Syntaxin 1a 一抗
  • 描述
    兔单克隆抗体[SP36] to Syntaxin 1a
  • 宿主
    Rabbit
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide within Human Syntaxin 1a aa 50-150 (N terminal). The exact sequence is proprietary.
    Database link: Q16623

  • 表位
    N terminus
  • 阳性对照
    • Human brain tissue

性能

应用

Our Abpromise guarantee covers the use of ab73913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

1/100 for 30 minutes at room temperature Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes, followed by cooling at room temperature for 20 minutes.

靶标

  • 功能
    Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
  • 组织特异性
    Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
  • 疾病相关
    Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
  • 序列相似性
    Belongs to the syntaxin family.
    Contains 1 t-SNARE coiled-coil homology domain.
  • 细胞定位
    Secreted and Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.
  • Information by UniProt
  • 数据库链接
    • 别名
      • HPC 1 antibody
      • Neuron specific antigen HPC1 antibody
      • Neuron-specific antigen HPC-1 antibody
      • OTTHUMP00000174615 antibody
      • OTTHUMP00000174616 antibody
      • OTTHUMP00000174617 antibody
      • OTTHUMP00000174618 antibody
      • P35-1 antibody
      • STX1 antibody
      • STX1A antibody
      • STX1A_HUMAN antibody
      • SYN1A antibody
      • Syntaxin 1A (brain) antibody
      • Syntaxin 1A brain antibody
      • Syntaxin-1A antibody
      see all

    图片

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syntaxin 1a antibody [SP36] (ab73913)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syntaxin 1a antibody [SP36] (ab73913)
      ab73913, at a 1/100 dilution, staining Syntaxin 1a in formalin fixed, paraffin embedded human brain tissue by Immunohistochemistry.

    文献

    ab73913 has not yet been referenced specifically in any publications.

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