Anti-Syntaxin 16抗体- Drosophila Golgi/Trans-Golgi Marker (ab32340)

概述

  • 产品名称
    Anti-Syntaxin 16抗体- Drosophila Golgi/Trans-Golgi Marker
    参阅全部 Syntaxin 16 一抗
  • 描述
    兔多克隆抗体to Syntaxin 16 - Drosophila Golgi/Trans-Golgi Marker
  • 经测试应用
    适用于: IHC-P, WBmore details
    不适用于: ICC/IF
  • 种属反应性
    与反应: Drosophila melanogaster
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 200 - 300 of Fruit fly (Drosophila melanogaster) Syntaxin 16.

    (Peptide available as ab32339.)

  • 阳性对照
    • Schneider L2 (Fruit fly (Drosophila melanogaster)) Whole cell lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 1% BSA, PBS. pH 7.4
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab32340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration. PubMed: 20935638
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa).Can be blocked with D. melanogaster Syntaxin 16 peptide (ab32339).
  • 应用说明
    Is unsuitable for ICC/IF.
  • 靶标

    • 功能
      SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
    • 组织特异性
      Ubiquitous.
    • 疾病相关
      Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B) [MIM:603233]. Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B.
    • 序列相似性
      Belongs to the syntaxin family.
      Contains 1 t-SNARE coiled-coil homology domain.
    • 细胞定位
      Cytoplasm and Golgi apparatus membrane.
    • Information by UniProt
    • 别名
      • hsyn16 antibody
      • MGC90328 antibody
      • Stx16 antibody
      • STX16_HUMAN antibody
      • Syn16 antibody
      • Syntaxin-16 antibody
      see all

    Anti-Syntaxin 16 antibody - Drosophila Golgi/Trans-Golgi Marker 图像

    • Anti-Syntaxin 16 antibody - Drosophila Golgi/Trans-Golgi Marker (ab32340) at 1 µg/ml + Schneider L2 whole cell lysate (ab14893) at 20 µg

      Secondary
      IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilution

      Performed under reducing conditions.

      Predicted band size : 40 kDa
      Observed band size : 40 kDa

    Anti-Syntaxin 16 antibody - Drosophila Golgi/Trans-Golgi Marker (ab32340)参考文献

    This product has been referenced in:
    • Charng WL  et al. Drosophila Tempura, a novel protein prenyltransferase a subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol 12:e1001777 (2014). ICC/IF ; Drosophila melanogaster . Read more (PubMed: 24492843) »
    • Hornbruch-Freitag C  et al. Drosophila Swiprosin-1/EFHD2 accumulates at the prefusion complex stage during Drosophila myoblast fusion. J Cell Sci 124:3266-78 (2011). ICC/IF ; Drosophila melanogaster . Read more (PubMed: 21896648) »

    See all 3 Publications for this product

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