概述

  • 产品名称
    Anti-Syntaxin 13抗体[15G2]
  • 描述
    小鼠单克隆抗体[15G2] to Syntaxin 13
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Hamster, Dog
  • 免疫原

    Recombinant full length protein (Rat).

  • 阳性对照
    • Rat or Mouse Brain Tissue Extract.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: 50% Glycerol, PBS, pH 7.2
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 克隆
    单克隆
  • 克隆编号
    15G2
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab13261 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明
    WB: Use at a concentration of 1 µg/ml. Detects a band of approximately 38 kDa. Additional bands of 27 and 37 kDa may also be recognized, and are believed to correspond to degradation products of syntaxin 13.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性
      Syntaxin 13 is an integral membrane protein that belongs to the t-SNARE family, a group of proteins involved in protein transport. Confocal immunofluoresence and electron microscopy studies have shown that syntaxin 13 is primarily localized to tubular early and recycling endosomes, where it colocalizes with transferrin receptor, and it is also localized in endosomal vacuoles. Syntaxin 13 has been found to be expressed in all tissues, with higher levels of the protein found in brain, lung, spleen, thymus and testes. Immunoprecipitation studies show that syntaxin 13 complexes with beta-SNAP, VAMP2/3, and SNAP25. The binding of this complex to alpha-SNAP and NSF is terminated in the presence of ATP. These results suggest that syntaxin 13 is a SNARE protein which mediates the recycling protein flow through tubulo vesicular recycling endosomes.
    • 细胞定位
      Tubular early and recycling endosomes and endosomal vacuoles.
    • 别名
      • Dm Syx13 antibody
      • ff16 antibody
      • Syntaxin13 antibody
      • Syx13 antibody

    实验方案

    Anti-Syntaxin 13 antibody [15G2] (ab13261)参考文献

    This product has been referenced in:
    • Suh YH  et al. Deletion of SNAP-23 Results in Pre-Implantation Embryonic Lethality in Mice. PLoS One 6:e18444 (2011). WB ; Mouse . Read more (PubMed: 21479242) »
    • Sobota JA  et al. Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins. J Cell Sci 122:3542-53 (2009). WB ; Mouse . Read more (PubMed: 19737820) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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