概述

  • 产品名称Anti-SynCAM抗体
    参阅全部 SynCAM 一抗
  • 描述
    兔多克隆抗体to SynCAM
  • 经测试应用适用于: WB, ELISA, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from C-terminal of human CADM1.

  • 阳性对照
    • HeLa cells.

性能

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应用

Our Abpromise guarantee covers the use of ab64872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
ELISA 1/20000.
ICC/IF Use a concentration of 1 - 5 µg/ml.

靶标

  • 功能Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
  • 序列相似性Belongs to the nectin family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 结构域The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
  • 细胞定位Cell membrane. Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BL2 antibody
    • Cadm1 antibody
    • CADM1_HUMAN antibody
    • Cell adhesion molecule 1 antibody
    • DKFZp686F1789 antibody
    • IgSF4 antibody
    • IGSF4A antibody
    • Immunoglobulin superfamily member 4 antibody
    • MGC149785 antibody
    • MGC51880 antibody
    • NECL-2 antibody
    • NECL2 antibody
    • Nectin like 2 antibody
    • Nectin-like protein 2 antibody
    • RA175 antibody
    • SgIGSF antibody
    • Spermatogenic immunoglobulin superfamily antibody
    • ST17 antibody
    • sTSLC 1 antibody
    • Synaptic cell adhesion molecule antibody
    • SynCAM antibody
    • SynCAM1 antibody
    • TSLC-1 antibody
    • TSLC1 antibody
    • Tumor suppressor in lung cancer 1 antibody
    see all

Anti-SynCAM antibody 图像

  • All lanes : Anti-SynCAM antibody (ab64872) at 1/500 dilution

    Lane 1 : Extracts from HeLa cells with no immunising peptide
    Lane 2 : Extracts from HeLa cells with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 42 kDa
    Observed band size : 46 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 52 kDa. We are unsure as to the identity of these extra bands.

Anti-SynCAM antibody (ab64872)参考文献

ab64872 has not yet been referenced specifically in any publications.

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