Anti-Synaptophysin抗体[SYP02] (ab6245)

概述

  • 产品名称Anti-Synaptophysin抗体[SYP02]
    参阅全部 Synaptophysin 一抗
  • 描述
    小鼠单克隆抗体[SYP02] to Synaptophysin
  • 特异性This antibody reacts with neuroendocrine neoplasms of neural as well as epithelial types. This antibody is specific to a 38 kD protein.
  • 经测试应用适用于: IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    BALB/C mice were injected with a synthetic peptide encoding a region near the c-terminal end of the synaptophysin protein.

  • 阳性对照
    • Pancreas.

性能

应用

Our Abpromise guarantee covers the use of ab6245 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
IHC-Fr
  • 应用说明IHC-P: Use at an assay dependent dilution. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
    IHC-Fr: Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
    • 组织特异性Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
    • 疾病相关Mental retardation, X-linked, SYP-related
    • 序列相似性Belongs to the synaptophysin/synaptobrevin family.
      Contains 1 MARVEL domain.
    • 结构域The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
    • 翻译后修饰Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
    • 细胞定位Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Major synaptic vesicle protein p38 antibody
      • MRX96 antibody
      • MRXSYP antibody
      • Syn p38 antibody
      • Synaptophysin antibody
      • Syp antibody
      • SYPH antibody
      • SYPH_HUMAN antibody
      • SypI antibody
      see all

    Anti-Synaptophysin antibody [SYP02] 图像

    • ab6245 staining human pancreas by IHC-P.

    Anti-Synaptophysin antibody [SYP02] (ab6245)参考文献

    This product has been referenced in:
    • Fishbein TM  et al. Rejection reversibly alters enteroendocrine cell renewal in the transplanted small intestine. Am J Transplant 9:1620-8 (2009). IHC-Fr ; Human . Read more (PubMed: 19519821) »

    See 1 Publication for this product

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