Anti-Synaptophysin抗体[SP17] (ab24729)

概述

  • 产品名称Anti-Synaptophysin抗体[SP17]
    参阅全部 Synaptophysin 一抗
  • 描述
    小鼠单克隆抗体[SP17] to Synaptophysin
  • 特异性SP17 reacts with native, denatured and recombinant synaptic vesicle protein synaptophysin expressed in CHO cells.
  • 经测试应用适用于: WB, ICC, ELISAmore details
  • 种属反应性
    与反应: Rat, Human, Pig
  • 免疫原

    Tissue/ cell preparation of a crude synaptic preparation from the post mortem brain (Human)

  • 常规说明


    The antibody is particularly valueable for immunocytochemical studies of the brain due to its stability in formalin sections.

性能

应用

Our Abpromise guarantee covers the use of ab24729 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 40 kDa.
ICC 1/1000.
ELISA 1/5000.

靶标

  • 功能Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
  • 组织特异性Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
  • 疾病相关Mental retardation, X-linked, SYP-related
  • 序列相似性Belongs to the synaptophysin/synaptobrevin family.
    Contains 1 MARVEL domain.
  • 结构域The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
  • 翻译后修饰Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • 细胞定位Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Major synaptic vesicle protein p38 antibody
    • MRX96 antibody
    • MRXSYP antibody
    • Syn p38 antibody
    • Synaptophysin antibody
    • Syp antibody
    • SYPH antibody
    • SYPH_HUMAN antibody
    • SypI antibody
    see all

Anti-Synaptophysin antibody [SP17] (ab24729)参考文献

ab24729 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. Synaptophysin antibodies ab11105 and ab24729 are derived from two different monoclonal clones: [SP15] and [SP17]. They were raised against different immunogens and recognise different epitopes. Both antisera have als...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"