Anti-Synaptophysin抗体[4E206] (ab18008)

概述

  • 产品名称Anti-Synaptophysin抗体[4E206]
    参阅全部 Synaptophysin 一抗
  • 描述
    小鼠单克隆抗体[4E206] to Synaptophysin
  • 经测试应用适用于: WB, IP, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Cow, Human
  • 免疫原

    Synaptic vesicle-containing fractions immunoprecipitated from human brain homogenates using anti-human Synaptophysin monoclonal antibodies.

  • 阳性对照
    • Mouse and rat brain tissue extract. No reactivity was detected in mouse liver extracts.

性能

应用

Our Abpromise guarantee covers the use of ab18008 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000. Detects a band of approximately 38 kDa.
IP 1/100.
IHC-P Use at an assay dependent dilution.

靶标

  • 功能Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
  • 组织特异性Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
  • 疾病相关Mental retardation, X-linked, SYP-related
  • 序列相似性Belongs to the synaptophysin/synaptobrevin family.
    Contains 1 MARVEL domain.
  • 结构域The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
  • 翻译后修饰Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • 细胞定位Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Major synaptic vesicle protein p38 antibody
    • MRX96 antibody
    • MRXSYP antibody
    • Syn p38 antibody
    • Synaptophysin antibody
    • Syp antibody
    • SYPH antibody
    • SYPH_HUMAN antibody
    • SypI antibody
    see all

Anti-Synaptophysin antibody [4E206] (ab18008)参考文献

This product has been referenced in:
  • Lee J  et al. Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma. Cancer Res 70:10131-40 (2010). Read more (PubMed: 21159635) »
  • Winden KD  et al. The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol 5:291 (2009). WB ; Mouse . Read more (PubMed: 19638972) »

See all 4 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Rat Tissue lysate - other (Cortex)
Loading amount 50 µg
Specification Cortex
Blocking step Milk as blocking agent for 45 minute(s) · Concentration: 5%
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提交于 Jan 15 2007

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"