The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
功能Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
疾病相关Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
序列相似性Belongs to the synapsin family.
翻译后修饰Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
Immunohistochemistry (Paraffin-embedded sections) - Synapsin I (phospho S62) antibody (ab59262)
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab95262 at a dilution of 1/50-1/100. Left hand image - without immunising peptide; right hand image - with immunising peptide.
Anti-Synapsin I (phospho S62) antibody (ab59262)参考文献
has not yet been referenced specifically in any publications.