Anti-Synapsin I (phospho S603)抗体(ab13879)
Key features and details
- Rabbit polyclonal to Synapsin I (phospho S603)
- Suitable for: WB
- Isotype: IgG
概述
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产品名称
Anti-Synapsin I (phospho S603)抗体
参阅全部 Synapsin I 一抗 -
描述
兔多克隆抗体to Synapsin I (phospho S603) -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
免疫原
Synthetic peptide corresponding to Rat Synapsin I (phospho S603).
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常规说明
Aliquots may be taken without freeze/thawing due to the presence of 50% glycerol.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.50
Constituents: 0.238% HEPES, 0.87% Sodium chloride, 0.01% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
The antibody was purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab13879于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000. Predicted molecular weight: 84.6 kDa.
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说明 |
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WB
1/1000. Predicted molecular weight: 84.6 kDa. |
靶标
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功能
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. -
疾病相关
Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior. -
序列相似性
Belongs to the synapsin family. -
翻译后修饰
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR. -
细胞定位
Cell junction > synapse. Golgi apparatus. - Information by UniProt
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别名
- Brain protein 4.1 antibody
- SYN 1 antibody
- SYN 1a antibody
see all
图片
数据表及文件
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Datasheet download
文献 (3)
ab13879 被引用在 3 文献中.
- Yan P et al. Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons. Cell Death Dis 13:786 (2022). PubMed: 36097267
- Arias-Cavieres A et al. Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction. Front Cell Neurosci 12:403 (2018). PubMed: 30459562
- Arias-Cavieres A et al. Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats. Front Mol Neurosci 11:429 (2018). PubMed: 30534053