Anti-Synapsin I (phospho S549)抗体(ab60070)

概述

  • 产品名称Anti-Synapsin I (phospho S549)抗体
    参阅全部 Synapsin I 一抗
  • 描述
    兔多克隆抗体to Synapsin I (phospho S549)
  • 特异性ab60070 recognises synapsin I, phosphorylated at serine residue 549.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Cow, Dog, Human, Non Human Primates
  • 免疫原

    Phosphopeptide corresponding to amino acid sequence surrounding the phosphorylated serine 549 of synapsin I.

  • 阳性对照
    • Rat cortex cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab60070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 74 kDa.

靶标

  • 功能Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • 疾病相关Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
  • 序列相似性Belongs to the synapsin family.
  • 翻译后修饰Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cell junction > synapse. Golgi apparatus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Brain protein 4.1 antibody
    • SYN 1 antibody
    • SYN 1a antibody
    • SYN 1b antibody
    • SYN I antibody
    • SYN1 antibody
    • SYN1_HUMAN antibody
    • SYN1a antibody
    • SYN1b antibody
    • Synapsin 1 antibody
    • Synapsin I antibody
    • Synapsin-1 antibody
    • Synapsin1 antibody
    • SynapsinI antibody
    • SYNI antibody
    see all

Anti-Synapsin I (phospho S549) antibody (ab60070)参考文献

ab60070 has not yet been referenced specifically in any publications.

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