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功能
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
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组织特异性
Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
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序列相似性
Contains 1 PH domain.
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结构域
The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
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翻译后修饰
Tyrosine-phosphorylated.
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细胞定位
Cytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
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Information by UniProt
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数据库链接
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别名
- KIAA0640 antibody
- 70kDa antibody
- AV235546 antibody
- FLJ39540 antibody
- HSPC321 antibody
- SWA 70 protein antibody
- SWAP 70 antibody
- SWAP switching B-cell complex 70kDa subunit antibody
- SWAP-70 antibody
- SWAP70 antibody
- Switch associated protein 70 antibody
- Switch-associated protein 70 antibody
- SWP70_HUMAN antibody
see all