概述

  • 产品名称Anti-SWAP70抗体
    参阅全部 SWAP70 一抗
  • 描述
    兔多克隆抗体to SWAP70
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow, Dog, Chimpanzee
  • 免疫原

    Synthetic peptide, sequence taken from within amino acids 300-350 of human SWAP-70.

  • 阳性对照
    • Daudi cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab47084 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 69 kDa).

靶标

  • 功能Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
  • 组织特异性Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
  • 序列相似性Contains 1 PH domain.
  • 结构域The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
  • 翻译后修饰Tyrosine-phosphorylated.
  • 细胞定位Cytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KIAA0640 antibody
    • 70kDa antibody
    • AV235546 antibody
    • FLJ39540 antibody
    • HSPC321 antibody
    • SWA 70 protein antibody
    • SWAP 70 antibody
    • SWAP switching B-cell complex 70kDa subunit antibody
    • SWAP-70 antibody
    • SWAP70 antibody
    • Switch associated protein 70 antibody
    • Switch-associated protein 70 antibody
    • SWP70_HUMAN antibody
    see all

Anti-SWAP70 antibody 图像

  • Anti-SWAP70 antibody (ab47084) at 2 µg/ml + Daudi cell lysate

    Predicted band size : 69 kDa
    Observed band size : 65 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

Anti-SWAP70 antibody (ab47084)参考文献

ab47084 has not yet been referenced specifically in any publications.

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