概述

  • 产品名称Anti-SUR1抗体
    参阅全部 SUR1 一抗
  • 描述
    山羊多克隆抗体to SUR1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Guinea pig, Dog
  • 免疫原

    Synthetic peptide:

    EFDKPEKLLSRKD

    (Human) from the C terminal of the protein sequence according to NP_000343.2.

  • 阳性对照
    • Human brain (cerebellum) lysates

性能

应用

Our Abpromise guarantee covers the use of ab77478 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Antibody detection limit dilution 1/8000.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 23 and 170 kDa (predicted molecular weight: 177 kDa). The 23 kDa band was successfully blocked by incubation with the immunising peptide.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.
    • 疾病相关Defects in ABCC8 are a cause of leucine-induced hypoglycemia (LIH) [MIM:240800]; also known as leucine-sensitive hypoglycemia of infancy. LIH is a rare cause of hypoglycemia and is described as a condition in which symptomatic hypoglycemia is provoked by high protein feedings. Hypoglycemia is also elicited by administration of oral or intravenous infusions of a single amino acid, leucine.
      Defects in ABCC8 are the cause of familial hyperinsulinemic hypoglycemia type 1 (HHF1) [MIM:256450]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.
      Defects in ABCC8 are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
      Defects in ABCC8 are the cause of transient neonatal diabetes mellitus type 2 (TNDM2) [MIM:610374]. Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. Transient neonatal diabetes remits early, with a possible relapse during adolescence.
    • 序列相似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
      Contains 2 ABC transmembrane type-1 domains.
      Contains 2 ABC transporter domains.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ABC36 antibody
      • Abcc8 antibody
      • ABCC8_HUMAN antibody
      • ATP binding cassette sub family C (CFTR/MRP) member 8 antibody
      • ATP binding cassette transporter sub family C member 8 (1) antibody
      • ATP-binding cassette sub-family C member 8 antibody
      • HHF1 antibody
      • HI antibody
      • HRINS antibody
      • MRP8 antibody
      • PHHI antibody
      • Sulfonylurea receptor (hyperinsulinemia) antibody
      • Sulfonylurea receptor 1 antibody
      • SUR antibody
      • SUR1 antibody
      • SUR1delta2 antibody
      • TNDM2 antibody
      see all

    Anti-SUR1 antibody 图像

    • Anti-SUR1 antibody (ab77478) at 0.5 µg/ml + human cerebellum lysate in RIPA buffer at 35 µg

      Predicted band size : 177 kDa
      Observed band size : 170 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 23 kDa. We are unsure as to the identity of these extra bands.

    Anti-SUR1 antibody (ab77478)参考文献

    ab77478 has not yet been referenced specifically in any publications.

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