概述

  • 产品名称Anti-SUR1抗体
    参阅全部 SUR1 一抗
  • 描述
    小鼠单克隆抗体to SUR1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: SEFLSSAEIR EEQCAPHEPT PQGPASKYQA VPLRVVNRKR PAREDCRGLT GPLQSLVPSA DGDADNCCVQ IMGGYFTWTP DGIPTLSNIT IRIPRGQLTM , corresponding to amino acids 611-711 of Human SUR1

应用

Our Abpromise guarantee covers the use of ab57459 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.
    • 疾病相关Defects in ABCC8 are a cause of leucine-induced hypoglycemia (LIH) [MIM:240800]; also known as leucine-sensitive hypoglycemia of infancy. LIH is a rare cause of hypoglycemia and is described as a condition in which symptomatic hypoglycemia is provoked by high protein feedings. Hypoglycemia is also elicited by administration of oral or intravenous infusions of a single amino acid, leucine.
      Defects in ABCC8 are the cause of familial hyperinsulinemic hypoglycemia type 1 (HHF1) [MIM:256450]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.
      Defects in ABCC8 are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
      Defects in ABCC8 are the cause of transient neonatal diabetes mellitus type 2 (TNDM2) [MIM:610374]. Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. Transient neonatal diabetes remits early, with a possible relapse during adolescence.
    • 序列相似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
      Contains 2 ABC transmembrane type-1 domains.
      Contains 2 ABC transporter domains.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ABC36 antibody
      • Abcc8 antibody
      • ABCC8_HUMAN antibody
      • ATP binding cassette sub family C (CFTR/MRP) member 8 antibody
      • ATP binding cassette transporter sub family C member 8 (1) antibody
      • ATP-binding cassette sub-family C member 8 antibody
      • HHF1 antibody
      • HI antibody
      • HRINS antibody
      • MRP8 antibody
      • PHHI antibody
      • Sulfonylurea receptor (hyperinsulinemia) antibody
      • Sulfonylurea receptor 1 antibody
      • SUR antibody
      • SUR1 antibody
      • SUR1delta2 antibody
      • TNDM2 antibody
      see all

    Anti-SUR1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57459 SUR1 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-SUR1 antibody (ab57459)参考文献

    This product has been referenced in:
    • Rufino AT  et al. Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing. J Cell Biochem 114:1879-89 (2013). WB ; Human . Read more (PubMed: 23494827) »

    See 1 Publication for this product

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