Anti-Suppressor of Fused抗体(ab118596)

概述

  • 产品名称Anti-Suppressor of Fused抗体
    参阅全部 Suppressor of Fused 一抗
  • 描述
    山羊多克隆抗体to Suppressor of Fused
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:

    AELRPSGAPGPT-C

    , corresponding to amino acids 2-13 of Human Suppressor of Fused (NP_057253.2).

  • 阳性对照
    • Human prostate and tonsil tissues

性能

应用

Our Abpromise guarantee covers the use of ab118596 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

靶标

  • 功能Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24311597, PubMed:24217340). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for normal embryonic development. Required for the proper formation of hair follicles and the control of epidermal differentiation.
  • 组织特异性Ubiquitous in adult tissues. Detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos. Isoform 1 is detected in fetal brain, lung, kidney and testis. Isoform 2 is detected in fetal testis, and at much lower levels in fetal brain, lung and kidney.
  • 疾病相关Medulloblastoma
  • 序列相似性Belongs to the SUFU family.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • OTTHUMP00000020374 antibody
    • OTTHUMP00000020377 antibody
    • OTTHUMP00000020379 antibody
    • PRO1280 antibody
    • SU FU antibody
    • SU(F)U antibody
    • Su(fu) antibody
    • SUFU antibody
    • SUFU negative regulator of hedgehog signaling antibody
    • SUFU_HUMAN antibody
    • SUFUH antibody
    • SUFUXL antibody
    • Suppressor of fused homolog (Drosophila) antibody
    • Suppressor of fused homolog antibody
    see all

Anti-Suppressor of Fused antibody 图像

  • ab118596, at 7.5 µg/ml, staining Suppressor of Fused in formalin fixed, paraffin embedded Human prostate tissue by Immunohistochemistry.
  • ab118596, at 7.5 µg/ml, staining Suppressor of Fused in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry.

Anti-Suppressor of Fused antibody (ab118596)参考文献

ab118596 has not yet been referenced specifically in any publications.

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