Anti-Superoxide Dismutase 1抗体(HRP) (ab6574)

概述

  • 产品名称Anti-Superoxide Dismutase 1抗体(HRP)
    参阅全部 Superoxide Dismutase 1 一抗
  • 描述
    兔多克隆抗体to Superoxide Dismutase 1 (HRP)
  • 偶联物HRP
  • 经测试应用适用于: WB, Dot blot, ELISAmore details
  • 种属反应性
    与反应: Cow
  • 免疫原

    Superoxide Dismutase [Bovine erythrocytes]

  • 常规说明

    Restore with 2.0 ml of deionized water (or equivalent). For extended storage reconstitute product with 50% glycerol instead of water and then aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

    Antibody reacts with superoxide dismutase from bovine erythrocytes showing a 33 kDa band against this metallo-enzyme (Cu2+-Zn2+). The enzyme catalyzes the destruction of O2- and protects against harmful free radical effects. SOD is found in the CSF of patients with brain tumors although not readily detected in normal brain. Suitable for most immunological assays, including SOD quantitation in RBCs.

性能

应用

Our Abpromise guarantee covers the use of ab6574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration.
Dot blot Use at an assay dependent concentration.
ELISA 1/1000 - 1/2000.

靶标

  • 功能Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
  • 疾病相关Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.
  • 序列相似性Belongs to the Cu-Zn superoxide dismutase family.
  • 翻译后修饰Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
    The ditryptophan cross-link at Trp-33 is reponsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required.
  • 细胞定位Cytoplasm. The pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALS antibody
    • ALS1 antibody
    • Amyotrophic lateral sclerosis 1 adult antibody
    • Cu/Zn SOD antibody
    • Cu/Zn superoxide dismutase antibody
    • Epididymis secretory protein Li 44 antibody
    • HEL S 44 antibody
    • Homodimer antibody
    • hSod1 antibody
    • Indophenoloxidase A antibody
    • IPOA antibody
    • Mn superoxide dismutase antibody
    • SOD antibody
    • SOD soluble antibody
    • SOD1 antibody
    • SOD2 antibody
    • SODC antibody
    • SODC_HUMAN antibody
    • Superoxide dismutase [Cu-Zn] antibody
    • Superoxide dismutase 1 antibody
    • Superoxide dismutase 1 soluble antibody
    • Superoxide dismutase Cu Zn antibody
    • Superoxide dismutase cystolic antibody
    see all

Anti-Superoxide Dismutase 1 antibody (HRP) (ab6574)参考文献

ab6574 has not yet been referenced specifically in any publications.

Product Wall

Reactivity to SOD3 is unknown.

The immunogen we used to make this antibody is the native whole protein derived from Bovine erythrocytes. The epitope which is involved in binding to the antibody is unknown.

We do not have an antibody specific for extracellular SOD.

Cross reactivity against Superoxide Dismutase from other species is highly probable (due to conservation of this molecule across species) but has not not been specifically determined. This antibody can be detected directly with ECL. However greate...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"