Anti-SUN2抗体(ab87036)
Key features and details
- Rabbit polyclonal to SUN2
- Suitable for: ICC
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-SUN2抗体
参阅全部 SUN2 一抗 -
描述
兔多克隆抗体to SUN2 -
宿主
Rabbit -
经测试应用
适用于: ICCmore details -
种属反应性
与反应: Mouse -
免疫原
Synthetic peptide:
MSRRSQRLTRYSQDDNDG
, corresponding to N terminal amino acids 1-18 of Mouse SUN2 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.1% Sodium azide
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab87036于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC |
1/500.
|
说明 |
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ICC
1/500. |
靶标
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相关性
SUN proteins form part of the LINC complex - a protein bridge that spans the nuclear envelope linking the nucleoskeleten to the actin cytoskeleten. They are located on the inner nuclear membrane side of the complex. The LINC complex is thought to function in controlling nuclear position, contributing to mechanical resistance and the overall architecture of the cell. SUN2 can exist in a heterodimer with SUN1. Both can interact with lamins and nesprins in the nuclear envelope. -
细胞定位
Nuclear membrane, endosome membrane, mitotic spindle organization. -
数据库链接
- Entrez Gene: 223697 Mouse
- SwissProt: Q8BJS4 Mouse
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别名
- FRIGG antibody
- KIAA0668 antibody
- nuclear envelope protein antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab87036 被引用在 8 文献中.
- Byron A et al. Characterisation of a nucleo-adhesome. Nat Commun 13:3053 (2022). PubMed: 35650196
- Östlund C et al. Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets. J Lipid Res 63:100277 (2022). PubMed: 36100089
- Antoku S et al. ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy. Dev Cell 51:602-616.e12 (2019). PubMed: 31794718
- Saunders CA et al. TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement. J Cell Biol 216:657-674 (2017). PubMed: 28242745
- Yang Z et al. Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb. Mol Cancer Res 15:1579-1586 (2017). PubMed: 28811362
- Zhu R et al. Centrifugal Displacement of Nuclei Reveals Multiple LINC Complex Mechanisms for Homeostatic Nuclear Positioning. Curr Biol 27:3097-3110.e5 (2017). PubMed: 28988861
- Gutiérrez-Fernández A et al. Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid. EMBO J 34:1875-88 (2015). PubMed: 25991604
- Guo Y & Zheng Y Lamins position the nuclear pores and centrosomes by modulating dynein. Mol Biol Cell 26:3379-89 (2015). ICC/IF . PubMed: 26246603