概述

  • 产品名称Anti-SUMF1抗体
    参阅全部 SUMF1 一抗
  • 描述
    山羊多克隆抗体to SUMF1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-ETLNPKGPPSGKDR

    , corresponding to internal sequence amino acids 314-327 of Human SUMF1 (NP_877437.2).

  • 阳性对照
    • Mouse pancreas, Mouse eye and Human kidney lysates

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab91479 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab91479 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 40 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE.
    • 组织特异性Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart.
    • 通路Protein modification; sulfatase oxidation.
    • 疾病相关Defects in SUMF1 are the cause of multiple sulfatase deficiency (MSD) [MIM:272200]. MSD is a clinically and biochemically heterogeneous disorder caused by the simultaneous impairment of all sulfatases, due to defective post-translational modification and activation. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay. Inheritance is autosomal recessive.
    • 序列相似性Belongs to the sulfatase-modifying factor family.
    • 翻译后修饰N-glycosylated. Contains high-mannose-type oligosaccharides.
    • 细胞定位Endoplasmic reticulum lumen.
    • Information by UniProt
    • 数据库链接
    • 别名
      • MGC150436 antibody
      • AAPA3037 antibody
      • C alpha formylglycine generating enzyme 1 antibody
      • C-alpha-formylglycine-generating enzyme 1 antibody
      • FGE antibody
      • FGly generating enzyme antibody
      • MGC131853 antibody
      • Sulfatase modifying factor 1 [Precursor] antibody
      • Sulfatase-modifying factor 1 antibody
      • SUMF1 antibody
      • SUMF1_HUMAN antibody
      • UNQ3037 antibody
      see all

    Anti-SUMF1 antibody 图像

    Anti-SUMF1 antibody (ab91479)参考文献

    ab91479 has not yet been referenced specifically in any publications.

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